| 01 |  Christian McCaffreyRB1 · SF | 417 | 1,202 rush · 17 TD | 17 | 11.7 | 35.1 | ▼3.4 | | T1 |
| 04 |  Bijan RobinsonRB2 · ATL | 369 | 1,478 rush · 11 TD | 17 | 7.3 | 35.8 | ▲1.5 | | T2 |
| 05 |  Jahmyr GibbsRB3 · DET | 367 | 1,223 rush · 18 TD | 17 | 6.4 | 38.2 | ▼2.3 | | T2 |
| 07 |  Jonathan TaylorRB4 · IND | 360 | 1,585 rush · 20 TD | 17 | 7.7 | 37.4 | ▼8.3 | | T2 |
| 14 |  De'Von AchaneRB5 · MIA | 323 | 1,350 rush · 12 TD | 16 | 14.2 | 31 | ▼2.6 | | T3 |
| 21 |  James Cook IIIRB6 · BUF | 302 | 1,621 rush · 14 TD | 17 | 4.9 | 31.1 | ▼2.0 | | T4 |
| 24 |  Chase BrownRB7 · CIN | 281 | 1,019 rush · 11 TD | 17 | 6.9 | 29.1 | ▲6.6 | | T5 |
| 25 |  Derrick HenryRB8 · BAL | 280 | 1,595 rush · 16 TD | 17 | 7.8 | 29.2 | ▲4.0 | | T5 |
| 29 |  Kyren WilliamsRB9 · LAR | 263 | 1,252 rush · 13 TD | 17 | 8.5 | 22.4 | ▲0.1 | | T5 |
| 30 |  Travis Etienne Jr.RB10 · NO | 254 | 1,107 rush · 13 TD | 17 | 5.1 | 21.2 | ▲2.1 | | T5 |
| 33 |  Ashton JeantyRB11 · LV | 245 | 975 rush · 10 TD | 17 | 5.8 | 31.8 | ▼0.9 | | T6 |
| 35 |  Javonte WilliamsRB12 · DAL | 243 | 1,201 rush · 13 TD | 16 | 7.3 | 25 | ▼2.3 | | T6 |
| 37 |  Josh JacobsRB13 · GB | 237 | 929 rush · 14 TD | 15 | 4 | 31.7 | ▼4.5 | | T6 |
| 40 |  Saquon BarkleyRB14 · PHI | 230 | 1,140 rush · 9 TD | 16 | 5.6 | 19.2 | ▼1.0 | | T6 |
| 41 |  D'Andre SwiftRB15 · CHI | 229 | 1,087 rush · 10 TD | 16 | 5.8 | 22.6 | ▼0.2 | | T6 |
| 45 |  Kenny GainwellRB16 · TB | 221 | 537 rush · 8 TD | 17 | 3.5 | 29.5 | ▲4.5 | | T6 |
| 52 |  Jaylen WarrenRB17 · PIT | 217 | 958 rush · 8 TD | 16 | 7.8 | 19.8 | ▲1.1 | | T6 |
| 53 |  Rico DowdleRB18 · PIT | 216 | 1,076 rush · 7 TD | 17 | 3 | 32.4 | ▼4.1 | | T6 |
| 58 |  Breece HallRB19 · NYJ | 208 | 1,065 rush · 5 TD | 16 | 5.7 | 20.9 | ▼2.0 | | T6 |
| 59 |  RJ HarveyRB20 · DEN | 207 | 540 rush · 12 TD | 17 | 3.8 | 22.1 | ▲3.3 | | T6 |
| 60 |  TreVeyon HendersonRB21 · NE | 206 | 911 rush · 10 TD | 17 | 2.2 | 30.1 | ▲1.8 | | T6 |
| 69 |  Kenneth Walker IIIRB22 · KC | 192 | 1,027 rush · 5 TD | 17 | 3.8 | 20.1 | ▲0.1 | | T6 |
| 75 |  Tony PollardRB23 · TEN | 186 | 1,082 rush · 5 TD | 17 | 5.6 | 18.2 | ▲4.6 | | T6 |
| 81 |  Zach CharbonnetRB24 · SEA | 179 | 730 rush · 12 TD | 16 | 3.1 | 19.5 | ▲3.2 | | T6 |
| 85 |  Rhamondre StevensonRB25 · NE | 175 | 603 rush · 9 TD | 14 | 2 | 27.2 | ▲7.5 | | T6 |
| 95 |  Quinshon JudkinsRB26 · CLE | 168 | 827 rush · 7 TD | 14 | 4.7 | 21.5 | ▼1.0 | | T6 |
| 98 |  David MontgomeryRB27 · HOU | 165 | 716 rush · 8 TD | 17 | 1.4 | 14.3 | ▼2.2 | | T6 |
| 102 |  Tyrone Tracy Jr.RB28 · NYG | 161 | 740 rush · 4 TD | 15 | 4.3 | 24.7 | ▲4.0 | | T6 |
| 112 |  Woody MarksRB29 · HOU | 145 | 703 rush · 5 TD | 16 | 2.4 | 16.1 | ▼0.4 | | T6 |
| 115 |  Rachaad WhiteRB30 · WSH | 143 | 572 rush · 4 TD | 17 | 2.6 | 17.6 | ▼2.8 | | T6 |
| 116 |  Kyle MonangaiRB31 · CHI | 143 | 783 rush · 5 TD | 17 | 2.1 | 19 | ▼1.6 | | T6 |
| 117 |  Jacory Croskey-MerrittRB32 · WSH | 140 | 805 rush · 8 TD | 17 | 2 | 22.5 | ▲2.3 | | T6 |
| 121 |  Bucky IrvingRB33 · TB | 139 | 588 rush · 4 TD | 10 | 8.1 | 25.5 | ▼3.8 | | T6 |
| 125 |  Omarion HamptonRB34 · LAC | 136 | 545 rush · 5 TD | 9 | 3.5 | 27.5 | ▼0.7 | | T6 |
| 140 |  Jordan MasonRB35 · MIN | 129 | 758 rush · 6 TD | 16 | 2.1 | 12.6 | ▼1.8 | | T6 |
| 147 |  Cam SkatteboRB36 · NYG | 126 | 410 rush · 7 TD | 8 | 2.9 | 31 | ▲1.2 | | T6 |
| 149 |  Chuba HubbardRB37 · CAR | 125 | 511 rush · 4 TD | 15 | 2.5 | 18.7 | ▼1.1 | | T6 |
| 153 |  Tyler AllgeierRB38 · ARI | 123 | 514 rush · 8 TD | 17 | 1.4 | 15 | ▼2.4 | | T6 |
| 156 |  Blake CorumRB39 · LAR | 122 | 746 rush · 6 TD | 17 | 1.5 | 14.1 | ▲5.2 | | T6 |
| 160 |  Aaron Jones Sr.RB40 · MIN | 119 | 548 rush · 3 TD | 12 | 4.5 | 15.7 | ▼0.3 | | T6 |
| 163 |  Kimani VidalRB41 · LAC | 118 | 643 rush · 4 TD | 13 | 1.1 | 20.7 | ▼0.9 | | T6 |
| 169 |  J.K. DobbinsRB42 · DEN | 116 | 772 rush · 4 TD | 10 | 6.9 | 15.5 | ▼2.9 | | T6 |
| 178 |  Tyjae SpearsRB43 · TEN | 112 | 283 rush · 2 TD | 13 | 1.4 | 17.2 | ▲0.3 | | T6 |
| 186 |  Devin SingletaryRB44 · NYG | 107 | 437 rush · 5 TD | 17 | 0.9 | 17.7 | ▲4.3 | | T6 |
| 192 |  Alvin KamaraRB45 · NO | 101 | 471 rush · 1 TD | 11 | 3.5 | 14.5 | ▼2.9 | | T6 |
| 194 |  Ty JohnsonRB46 · BUF | 100 | 200 rush · 5 TD | 17 | 0.6 | 15 | ▲3.4 | | T6 |
| 196 |  Michael CarterRB47 · TEN | 99 | 333 rush · 1 TD | 13 | 0.4 | 13.4 | — | | T6 |
| 204 |  Bam KnightRB48 · ARI | 93 | 269 rush · 5 TD | 12 | 0 | 14.5 | ▲2.4 | | T6 |
| 205 |  Emanuel WilsonRB49 · SEA | 93 | 496 rush · 3 TD | 17 | 0.3 | 11.9 | ▼1.7 | | T6 |
| 208 |  Chris Rodriguez Jr.RB50 · JAX | 92 | 500 rush · 6 TD | 13 | 0.2 | 13.9 | ▲3.7 | | T6 |
| 210 |  Sean TuckerRB51 · TB | 91 | 320 rush · 8 TD | 17 | 0 | 10.2 | ▼0.9 | | T6 |
| 214 |  Bhayshul TutenRB52 · JAX | 89 | 307 rush · 7 TD | 15 | 1.1 | 13.4 | ▼0.6 | | T6 |
| 218 |  Dylan SampsonRB53 · CLE | 88 | 175 rush · 2 TD | 15 | 0.2 | 16.2 | ▲2.2 | | T6 |
| 219 |  Isiah PachecoRB54 · DET | 87 | 462 rush · 2 TD | 13 | 3 | 12.8 | ▼1.3 | | T6 |
| 230 |  Samaje PerineRB55 · CIN | 78 | 382 rush · 3 TD | 15 | 0.1 | 12.1 | ▲2.5 | | T6 |
| 249 |  Jeremy McNicholsRB56 · WSH | 71 | 221 rush · 1 TD | 17 | 0 | 11.8 | ▼1.8 | | T6 |
| 254 |  Isaiah DavisRB57 · NYJ | 69 | 236 rush · 1 TD | 16 | 0 | 13.5 | ▲1.4 | | T6 |
| 259 |  Justice HillRB58 · BAL | 65 | 93 rush · 3 TD | 10 | 0 | 28.7 | ▼2.2 | | T6 |
| 262 |  Brashard SmithRB59 · KC | 63 | 151 rush · 1 TD | 17 | 0 | 9.5 | ▲0.2 | | T6 |
| 265 |  Brian Robinson Jr.RB60 · ATL | 63 | 400 rush · 2 TD | 17 | 0.9 | 11.3 | ▼1.4 | | T6 |
| 272 |  Devin NealRB61 · NO | 60 | 206 rush · 2 TD | 10 | 0.1 | 15.4 | ▲4.5 | | T6 |
| 276 |  Emari DemercadoRB62 · KC | 58 | 312 rush · 1 TD | 13 | 0 | 10.1 | ▼0.5 | | T6 |
| 278 |  Ray DavisRB63 · BUF | 58 | 275 rush · 2 TD | 17 | 0 | 9.9 | ▲3.7 | | T6 |
| 281 |  Keaton MitchellRB64 · LAC | 55 | 341 rush · 1 TD | 13 | 0.2 | 7.6 | — | | T6 |
| 284 |  Ollie Gordon IIRB65 · MIA | 54 | 199 rush · 4 TD | 17 | -0.2 | 10.5 | ▼1.2 | | T6 |
| 286 |  Tank BigsbyRB66 · PHI | 54 | 356 rush · 2 TD | 17 | 0 | 10.4 | ▲3.9 | | T6 |
| 293 |  Justin JacksonRB67 · DET | 51 | 170 rush · 2 TD | 16 | 0 | 8.7 | ▲1.1 | | T6 |
| 306 |  Jaylen WrightRB68 · MIA | 48 | 288 rush · 2 TD | 10 | 0.4 | 16.7 | ▲3.3 | | T6 |
| 308 |  Audric EstimeRB69 · NO | 48 | 198 rush · 1 TD | 7 | 0 | 16.8 | ▲2.7 | | T6 |
| 315 |  Jerome FordRB70 · WSH | 44 | 73 rush · 0 TD | 13 | 0.1 | 8 | ▼1.8 | | T6 |
| 317 |  Salvon AhmedRB71 · CHI | 43 | 61 rush · 2 TD | 8 | 0 | 12.4 | ▲1.6 | | T6 |
| 319 |  Malik DavisRB72 · DAL | 41 | 250 rush · 2 TD | 10 | 0.3 | 11.7 | ▲3.1 | | T6 |
| 322 |  Zavier ScottRB73 · MIN | 39 | 114 rush · 1 TD | 16 | 0 | 6 | ▼0.9 | | T6 |
| 326 |  Ameer AbdullahRB74 · JAX | 38 | 60 rush · 1 TD | 13 | 0 | 6.6 | ▲0.7 | | T6 |
| 335 |  Tyler BadieRB75 · DEN | 35 | 23 rush · 0 TD | 16 | 0 | 4.6 | ▼0.2 | | T6 |
| 336 |  Pierre Strong Jr.RB76 · GB | 35 | 108 rush · 0 TD | 14 | — | — | — | — | T6 |
| 340 |  Kendre MillerRB77 · NO | 33 | 193 rush · 1 TD | 7 | 0.7 | 12.5 | ▲1.0 | | T6 |
| 342 |  Chris BrooksRB78 · GB | 33 | 106 rush · 0 TD | 17 | 0 | 5.7 | ▲0.6 | | T6 |
| 349 |  Jaleel McLaughlinRB79 · DEN | 31 | 187 rush · 1 TD | 8 | 0 | 8.4 | ▼0.1 | | T6 |
| 355 |  Patrick Taylor Jr.RB80 · SF | 30 | 183 rush · 1 TD | 13 | — | — | — | — | T6 |
| 367 |  Sincere McCormickRB81 · SF | 27 | 183 rush · 0 TD | 5 | — | — | — | — | T6 |
| 371 |  Jaret PattersonRB82 · LAC | 26 | 159 rush · 1 TD | 6 | 0.1 | 11.4 | ▲0.3 | | T6 |
| 374 |  LeQuint Allen Jr.RB83 · JAX | 25 | 94 rush · 0 TD | 17 | 0 | 2.8 | ▼0.1 | | T6 |
| 378 |  Rasheen AliRB84 · BAL | 24 | 24 rush · 1 TD | 15 | 0 | 3.3 | ▲2.3 | | T6 |
| 380 |  Carson SteeleRB85 · PHI | 24 | 183 rush · 0 TD | 17 | — | — | — | — | T6 |
| 384 |  Kenny McIntoshRB86 · SEA | 22 | 172 rush · 0 TD | 17 | 0 | 4.9 | ▲2.8 | | T6 |
| 386 |  Jaydon BlueRB87 · DAL | 20 | 129 rush · 1 TD | 5 | 0 | 12.4 | — | | T6 |
| 392 |  Will ShipleyRB88 · PHI | 20 | 49 rush · 0 TD | 15 | 0 | 3.3 | ▼0.5 | | T6 |
| 394 |  Israel AbanikandaRB89 · DAL | 18 | 70 rush · 0 TD | 6 | — | — | — | — | T6 |
| 413 |  Terrell JenningsRB90 · NE | 15 | 73 rush · 1 TD | 7 | 0 | 11.4 | ▲0.5 | | T6 |
| 414 |  George HolaniRB91 · SEA | 15 | 73 rush · 1 TD | 11 | 0 | 4.2 | ▲0.8 | | T6 |
| 423 |  Trevor EtienneRB92 · CAR | 14 | 94 rush · 0 TD | 17 | 0 | 3.3 | ▼0.5 | | T6 |
| 437 |  DJ GiddensRB93 · IND | 10 | 96 rush · 0 TD | 9 | 0 | 4.1 | — | | T6 |
| 439 |  AJ DillonRB94 · CAR | 9 | 60 rush · 0 TD | 7 | 0 | 2 | ▼0.1 | | T6 |
| 441 |  Kaleb JohnsonRB95 · PIT | 9 | 69 rush · 0 TD | 10 | 0.1 | 2.3 | ▼0.3 | | T6 |
| 444 |  British BrooksRB96 · HOU | 8 | 78 rush · 0 TD | 15 | 0 | 1.5 | ▲0.7 | | T6 |
| 458 |  Evan HullRB97 · HOU | 6 | 48 rush · 0 TD | 6 | 0.3 | 2 | ▼0.1 | | T6 |
| 459 |  Tahj BrooksRB98 · CIN | 6 | 45 rush · 0 TD | 16 | 0 | 1.7 | ▲0.3 | | T6 |
| 462 |  Dylan LaubeRB99 · LV | 6 | 9 rush · 0 TD | 17 | 0 | 1.4 | ▼0.7 | | T6 |
| 465 |  Tyler GoodsonRB100 · ATL | 5 | 24 rush · 0 TD | 11 | 0 | 1 | ▼0.2 | | T6 |